Search results for "Bioabsorbable scaffol"

showing 3 items of 3 documents

Electrospun PHEA-PLA/PCL Scaffold for Vascular Regeneration: A Preliminary in Vivo Evaluation

2017

Abstract Background There is increasing interest in the development of vessel substitutes, and many studies are currently focusing on the development of biodegradable scaffolds capable of fostering vascular regeneration. We tested a new biocompatible and biodegradable material with mechanical properties similar to those of blood vessels. Methods The material used comprises a mixture of α,β-poly(N-2-hydroxyethyl)- d,l -aspartamide (PHEA) and polylactic acid (PLA), combined with polycaprolactone (PCL) by means of electrospinning technique. Low-molecular-weight heparin was also linked to the copolymer. A tubular PHEA-PLA/PCL sample was used to create an arteriovenous fistula in a pig model wit…

ScaffoldMaterials scienceBiocompatibilityPolymersSwinePolyesters0206 medical engineering02 engineering and technologySettore MED/22 - Chirurgia VascolareNeovascularizationchemistry.chemical_compoundPolylactic acidBlood vessel prosthesismedicineAnimalsTransplantationRegeneration (biology)Bioabsorbable scaffold Bioengineered vascular scaffold Experimental surgery021001 nanoscience & nanotechnology020601 biomedical engineeringBlood Vessel ProsthesisSettore MED/18 - Chirurgia GeneraleCoagulative necrosischemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoPolycaprolactoneSurgerymedicine.symptomPeptides0210 nano-technologyBiomedical engineeringTransplantation Proceedings
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Electrospun Polyhydroxyethyl-Aspartamide-Polylactic Acid Scaffold for Biliary Duct Repair: A Preliminary In Vivo Evaluation

2017

Abstract Tissue engineering has emerged as a new approach with the potential to overcome the limitations of traditional therapies. The objective of this study was to test whether our polymeric scaffold is able to resist the corrosive action of bile and to support a cell's infiltration and neoangiogenesis with the aim of using it as a biodegradable tissue substitute for serious bile duct injuries. In particular, a resorbable electrospun polyhydroxyethyl-aspartamide–polylactic acid (90 mol% PHEA, 10 mol% PLA)/polycaprolactone (50:50 w/w) plate scaffold was implanted into rabbit gallbladder to assess the in vivo effects of the lytic action of the bile on the scaffold structure and then as a tu…

ScaffoldMaterials sciencePolyesters03 medical and health scienceschemistry.chemical_compound0302 clinical medicineBioabsorbable scaffold Bioengineered biliary duct Experimental surgeryTissue engineeringPolylactic acidIn vivomedicineAnimalsTransplantationTissue EngineeringTissue ScaffoldsBile ductGallbladderBiliary Tract Surgical ProceduresSettore MED/18 - Chirurgia Generalemedicine.anatomical_structurechemistryBiliary tractSettore CHIM/09 - Farmaceutico Tecnologico Applicativo030220 oncology & carcinogenesisPolycaprolactone030211 gastroenterology & hepatologySurgeryBile DuctsRabbitsBiomedical engineering
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Electrospun biodegradable materials for vascular regenerative medicine

2011

Objectives: There is a rising interest for the development of small-sized blood vessels substitutes. Several studies have been focused on the development of a biodegradable graft temporarily able to substitute the blood vessels and allow their complete regeneration after a certain time. We tried to develop a biodegradable material, with optimal mechanical characteristics and the capacity to allow cells adhesion, differentiation and proliferation by electrospinning to obtain a nano-fibrillar scaffold starting from a polymeric solution. Methods: We report the in vivo application on rats of two new electrospun biodegradable materials, specifically designed to create tubular structures. Both bi…

Settore MED/18 - Chirurgia GeneraleBioabsorbable scaffol; Biotechnology; Experimentl surgery; Vascular graftSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoExperimentl surgeryVascular graftSettore MED/22 - Chirurgia VascolareBioabsorbable scaffolBiotechnology
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